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Another study demonstrated beneficial effects of Yuzu extract via inhibition of cox-2 and suppression of monocyte chemotactic protein, TNF, interleukins, p38 phosphorylation and nitric oxide synthase in RAW264.7 cells

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However, in the presence of oxidative or nitrosative stress, GST can form homodimers that alter the reduced states of cysteine residues in its structure, resulting in JNK dissociation from the GSTJNK heterocomplex and causing subsequent activation of the c-Jun protein