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Carnosine exerts its effects by reducing zinc and copper influx near GABA receptors, thereby indirectly enhancing GABA function, particularly in the frontal cortex (182)

A 2024 study looked at postmenopausal women on semaglutide who were overweight or obese (the median BMI was 36)

These effects are associated with its activity as a nonselective agonist of melanocortin receptors, including MC1R, MC3R, and MC4R

The current challenges and costs of GLP-1 therapy highlight the urgent need for rigorous research on how staged or combination nutritional programs, including multiple components and possibly FIM therapies, might improve outcomes, mitigate weight regain or cycling, and promote health equity

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