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Trimetazidine attenuates exhaustive exercise-induced myocardial injury in rats via regulation of the Nrf2/NF-B signaling pathway

Heres how they likely work: Cooled coffee that sits in your rectum makes it back to your liver via enterohepatic circulation (2)

This can be done by binding to the enzyme's active site or by indirectly acting as an antioxidant and scavenging free radicals

doi: 10.1074/jbc.M802671200