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NAC and glutathione supplementation both help to boost antioxidant capacity

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The constant levels of marker proteins such as GAPDH, combined with observations indicating that knockdown of the UPR element, BiP/Grp78 , revealed no detectable effects on Nrf2, GCLC, or glutathione, further support the conclusion that NFT-mediated stabilization of Nrf2 is a major contributor to its accumulation and the subsequent stimulation of GCL and glutathione synthesis

Surprisingly, there is weak correlation between blood GSH and vitamin B 12 levels even in diabetic patients (both vitamin B 12 deficient and otherwise)

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