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Individual variation in GLP-1 receptor expression and gastrointestinal motility explains why one person tolerates a dose easily while another experiences significant symptoms at the same level

Common side effects of Zepbound include nausea, diarrhea, vomiting, constipation, stomach pain, indigestion, injection site reactions, feeling tired, allergic reactions, belching, hair loss, and/or heartburn

Specifically, glucagon-like peptide 1 receptor agonists (arGLP-1), such as semaglutide, have demonstrated a mean weight loss approaching the 15% threshold [18,19,20]

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However, these trials did not specifically recruit individuals with diagnosed BED, and eating disorder symptoms were not primary outcomes