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Conversely, guiding immune cells toward an anti-inflammatory phenotype, such as M2-skewed macrophages, can enhance lipid clearance and reduce iron overload in OA joints, potentially lowering ferroptosis incidence ( Figure 2 )

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Any of these symptoms warrant immediate fluid intake increase and potentially electrolyte supplementation

However, polyphenols can improve macrophage function by inhibiting lipopolysaccharide-induced iNOS expression, thereby reducing oxidative stress [60]

I feel like it will be the Wild West for the first six months at least. It will be a circus