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(2001) investigated AOD9604 in obese Zucker rats and observed that chronic administration was associated with reduced body weight gain without changes in IGF-1 levels or glucose tolerance, distinguishing its activity profile from that of full-length growth hormone [1]

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It is possible that additional satiety signals, such as glutamate 40 , GABA 41 , cholecystokinin (CCK) 42 , pro-opiomelanocortin (POMC) 43 , neuropeptide Y 44 , and/or norepinephrine 44 , are mediating the macronutrient-dependent feeding responses associated with NTS neuron activation

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