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Current therapies, such as NSAIDs, DMARDs, and targeted biologic treatments, often have significant limitations and side effects

Interestingly, IS exposure increased KEAP1 protein levels, a pattern that differs from the canonical model in which oxidative stress mainly inactivates KEAP1 via cysteine modification rather than elevating its abundance

Nutritional lifestyle intervention in obese pregnant women, including lower carbohydrate intake, is associated with increased maternal free fatty acids, 3--Hydroxybutyrate, and fasting glucose concentrations: a secondary factorial analysis of the European multicenter, randomized controlled DALI lifestyle intervention trial

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Missing doses or irregular timing disrupts this accumulation