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Telmisartan improves myocardial remodeling by inhibiting leptin autocrine activity and activating PPARgamma

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Clinical data shows that approximately 70% of weight lost returns within one year of discontinuing these medications, suggesting that sustained therapy may be necessary for durable results

The discovery set the stage for a decade of GLP-1 research and development, culminating in newer formulations with greater efficacy and longer dosing intervals