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The 1960s and 1970s brought radioimmunoassay technology and the identification of GIP (glucose-dependent insulinotropic polypeptide) as the first incretin hormone

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However, medicines such as semaglutide and liraglutide have been extensively investigated, and a majority of the adverse effects of GLP-1 medications are similar and mainly gastrointestinal 1

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A secondary objective was to evaluate the methodological approaches used in these studies to identify best practices for investigating and interpreting the effects of GLP-1 RAs on neuroaffective responses to motivationally relevant stimuli