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[DOI] [PMC free article] [PubMed] [Google Scholar] 91.Joshi K., Lad S., Kale M., Patwardhan B., Mahadik S.P., Patni B., Chaudhary A., Bhave S., Pandit A

The enzymes DNA methyltransferases catalyze the transfer of methyl groups, derived from SAM, to the CpG islands in the promoter region of a gene, preventing the interaction of this region with the transcriptional machinery and consequently blocking gene expression (Triantaphyllopoulos et al., 2016) ( Figure 1 )

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This not only enhances the efficacy of the treatment but also reduces systemic side effects, making mitochondria-targeted therapies more feasible and practical