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It also doesnt mean harm

Those with severe gastroparesis, inflammatory bowel disease, or frequent GI surgery are generally not candidates

doi: 10.2147/ccid.s128339

The trial was scheduled to last for 5 years, but was stopped after a median of only 3.3 years of follow up because subjects who underwent more intensive blood pressure lowering had a dramatic 25% risk reduction for a composite of cardiovascular outcomes and a 27% lower risk of death from any cause compared with the standard-treatment group

Growth hormone & IGF research: official journal of the Growth Hormone Research Society and the International IGF Research Society , 19 (5), 426431.