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Among weight-loss pharmacotherapies, glucagon-like peptide-1 receptor agonists (GLP-1 RAs), including dual GLP-1 and glucose-dependent insulinotrophic polypeptide (GIP) receptor agonists, have demonstrated efficacy in patients with and without CKD, and are increasingly regarded as cornerstone therapies to improve outcomes in patients with multiple comorbidities

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In patients who present with CSA, consider decreasing the opioid dosage using best practices for opioid taper [see Dosage and Administration]

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