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PGPIPN significantly decreased the mRNA levels of ACC and CHOP genes, and increased that of PPAR - gene in contrast

Furthermore, it has recently been reported that the induction of endoplasmic reticulum (ER) stress response, lens epithelial cell (LEC) apoptosis, and epithelial-mesenchymal transition (EMT) are implicated in the development of diabetic cataracts 15,16,17

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We found that this subgroup accounts for nearly 20% of patients with SSc and appears to define a distinct clinical phenotype, characterised by higher interstitial lung disease and myopathy burden, together with less severe vascular involvement