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doi: 10.1159/000335763

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Imaging analyses, laboratory testing, and clinical evaluation are typically used in combination for the diagnostic process

The D-retro-inverso design replaces all L-amino acids with D-amino acids and reverses the sequence a structural strategy that preserves the side-chain topology of the original FOXO4 binding region while making the peptide resistant to proteolytic degradation, dramatically extending plasma half-life compared to the natural L-form

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