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Importantly, these data suggest the possibility for no titration and once monthly dosing, which may result in a more convenient, more scalable, and better tolerated way to administer GLP-1 medicines. The randomized, placebo-controlled, double-blind Phase 1 trial was designed to evaluate the tolerability, pharmacokinetics, pharmacodynamics and efficacy of subcutaneous MET-097 in 125 healthy, non-diabetic, overweight or obese adult participants

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The FDA label for semaglutide (Wegovy) reports that 11 percent of trial participants experienced fatigue, a little bit more than twice as often as those who used a placebo

This demonstrates that treatment with liraglutide has the potential to act as a prophylactic treatment (McClean et al., 2015)

Its important to note that GLP-1s are not recommended for individuals with a history of pancreatitis