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a , Body weight of Control, Bmal1 -KO, and Bmal1 -KO + NDI1 mice at 4 months of age on a chow diet (n = 7 Control, n = 6 Bmal1 -KO, and n = 5 Bmal1 -KO + NDI1)

2 The Health Canada approval of Trulicity is based on data from the AWARD clinical trial program, designed to evaluate the safety and efficacy of dulaglutide in adults with type 2 diabetes

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Both compounds have attracted clinical interest due to their roles in energy metabolism, cardiovascular health, and potential therapeutic applications in various conditions characterised by mitochondrial dysfunction or energy deficiency

Additionally, these medications slow gastric emptying, which contributes to improved postprandial glucose control and promotes satiety, leading to reduced caloric intake and weight loss