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No consistent associations were observed for increased smoking behavior after multivariable adjustment for the remaining covariates
MC4R activity is regulated by the balance between two endogenous ligands: -melanocyte-stimulating hormone, derived from proopiomelanocortin (POMC), which activates MC4R and promotes satiety, and agouti-related peptide (AGRP), which inhibits MC4R by acting as a competitive antagonist and an inverse agonist, thus stimulating hunger [52]
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