They discovered that both patient groups exhibited signs of elevated oxidative stress
doi: 10.3389/fnut.2026.1695902 Received 30 August 2025 Revised 13 January 2026 Accepted 26 January 2026 Published 19 February 2026 Volume 13 - 2026 Edited by Yemin Wang, University of British Columbia, Canada Reviewed by Afreen Saif, King George Medical University, India Le Anh Minh Nguyen, Western University, Canada Jianan Geng, Jilin Agriculture University, China Updates Copyright 2026 Zhang, Xu, Wang, Shen, Sun, Zha and Wang
[75] tested the hypothesis that short-term (4 weeks total) NAC supplementation (no GLY) might improve glucose tolerance and/or beta-cell function in T2D
They required a delivery system that could carry glutathione past the stratum corneum to reach dermal fibroblasts, a feat impossible for standard formulations
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