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One study found that after 82 weeks of treatment with a GLP-1 receptor agonist (exenatide), people had better scores on a test that measures how their weight affects their quality of life, self-esteem, and work performance, compared to people treated with another diabetes medicine (insulin glargine)

Gut microbiome-based metagenomic signature for non-invasive detection of advanced fibrosis in human nonalcoholic fatty liver disease

Biochemical and biophysical research communications , 280 (1), 132138.

There is emerging evidence that GIPR agonism and antagonism exert their paradoxically similar effects on weight loss via distinct neuronal populations 6,12

Researchers arent only looking at fibroblast-related signaling or one tissue response