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For example, most major GLP-1 trials have enrolled people with obesity or diabetes

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The primary function of the GLP-1R is to bind the GLP-1 protein and its analogs and initiate signaling inside pancreatic -cells to release insulin

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Its value in a clinical setting comes from what it is not: it does not disrupt appetite, hormones, insulin, or IGF-1

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If you encounter any of these signs, discontinue the medication and promptly consult your doctor

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