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These modifications are caused by inflammation, hyperhomocysteinemia, oxidative stress, decreased angiogenic factors, and cellular senescence

Front Psychiatry 10 , 97 (2019)

inhibitors of protein kinase B (Akt), epidermal growth factor receptor (EGRF), tyrosine kinase 3 (Flt-3), mast/stem cell growth factor receptor (c-Kit/CD117), platelet-derived growth factor receptor, RNA-dependent protein kinase (PKR), bone morphogenic protein, AMP-activated protein kinase (AMPK),casein kinase2, andtumor progression locus2 kinase

Gastroenterology 169 , 4862 (2025)

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