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Given that GCL or GGT pharmacological inhibition or silencing effectively blocks the growth of lymphoid tumor cells in 3D gels, including TIC-like cells, we propose that high glutathione levels in the minority of tumor cells that thrive in 3D gels counteract ROS-induced cell death

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Homeostatic regulation of GSH levels Glutathione peroxidase (GPx), glutathione reductase (GR), glutathione S-transferase (GST), and glucose-6-phosphate dehydrogenase (G6PD) are responsible for recycling of oxidized glutathione (GSSG) back to reduced glutathione (GSH)