Last Published 06.01.2026 Effective Date: 06.01.2026 This policy addresses the use of Oxlumo (Lumasiran) and Rivfloza (Nedosiran) for the treatment of primary hyperoxaluria type 1 (PH1)
Your provider will discuss realistic expectations for your specific treatment plan during your consultation
Switch to 500 mcg every other morning (EOD) as soon as Phase 1 effects are observed The every-other-day schedule reduces cumulative exposure while maintaining metabolic benefits Monitor how your body responds: appetite suppression should persist between doses at this frequency The shift from daily to EOD is not optional once effects are felt
When administered to rats within 30 minutes of experimental acetaminophen intoxication, 200 mg/kg of curcumin prevented the microscopic appearance of kidney damage, prevented elevations in renal lipid peroxidation, and maintained glutathione levels compared to control rats (Cekmen 2009)
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