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To account for advancements in medical practice, we performed an additional analysis of patients enrolled before and after 2022

In this process, the ubiquitin-proteasome system (UPS), recognized as the principal proteolytic pathway, becomes highly active under pathological conditions such as metabolic muscle atrophy 34

Clinical trials demonstrate substantial weight loss with both compounds

Fifth, in some studies, hazard ratios were derived from time-to-event data or calculated from secondary endpoints, which may have introduced variability in effect estimates

According to the molecular functions, the DAPs for T2/T1, T4/T1 and T4 /T3 were classified into nine functional categories