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GSH/system Xc-/GPX4 pathway GSH is a tripeptide composed of three amino acids (cysteine, glutamate, and glycine) and is one of the most abundant antioxidants in cells [63]

Numerous studies demonstrated that EVOO plays a cardioprotective role, exerts a protective effect against atherosclerosis, lowers blood pressure, improves cognitive performance, verbal fluency, and visual memory, glucose metabolism, and reduces the occurrence of Parkinsons and Alzheimers diseases [19,20]

For example, in the case of GC, he and his research team found that -piperine can inhibit the interaction between OTU domain-containing protein 1 (OTUB1) and GPX4, thereby promoting the ubiquitination and degradation of GPX4 and ultimately triggering the ferroptosis of gastric adenocarcinoma cells with radiation resistance

5) Home Remedies (Supportive, Not Miracles) Home remedies are often the first thing people try to remove dark circles , especially in Pakistan where these solutions are easily available and affordable

Annu Rev Anim Biosci