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Conclusion 4-5: The lack of validated mechanistic biomarkers, beyond amyloid and tau, that can confirm that a pathway has been engaged by an intervention is compounded by the lack of markers that can act as a surrogate endpoint for assessing the efficacy of an intervention and limit the capacity of clinical trials to rapidly evaluate interventions

Whitney Bowe, clinical assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai Medical Center in New York

2026;394:e100077

Possibly, the common marmoset could be considered as a model ( Elucidation of the effects at the physiological level may lay the groundwork for medical applications to numerous conditions that are dependent on steroid hormones ( The function of GSTs in steroid metabolism in not limited to mammalian organisms, but has also been discovered in insects