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Anti-inflammatory drugs like glucocorticoids have been shown to limit the pro-inflammatory effects of neutrophils by downregulating key inflammatory factors, including IL-1, TNF-, and IL-8, thus diminishing the neutrophil mediated proinflammatory damage caused by neutrophilic stimuli such as pyocyanin (105, 106)
Importantly, obesity can also worsen pre-existing T2 high asthma, highlighting that its impact is not limited to the obesity-driven asthma endotype but extends across asthma phenotypes [38]
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Unlike most lizards, the Gila monster is not suited for high temperatures and therefore spends most of its life underground, emerging periodically to raid the nests of quails, rabbits, pack rats, or other vertebrates
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