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Acknowledgements We thank the 23andMe research participants and employees who made this study possible

10f-THF: 10-formyltetrahydrofolate 5mTHF: 5-methyltetrahydrofolate AICAR: P-ribosyl-5-amino-4-imidazole carboxamide CH = THF: 5-10-methenyltetrahydrofolate CH2-THF: 5-10-methylenetetrahydrofolate Cys: cysteine Cysta cystathionine DHF: dihydrofolate DMG: dimethylglycine dTMP: deoxythymidine monophosphate dUMP: deoxyuridine monophophate GAR: glycinamide ribonucleotide Glut: glutamate Glut: Cys glutamyl-cysteine Gly: glycine

Oral semaglutide adds an important layer of flexibility to GLP-1 therapy, especially for patients who may benefit from earlier treatment initiation and improved adherence

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These therapies can induce a body weight reduction of 10 to 20 percent, at times rapidly, along with both overt and camouflaged soft tissue alterations