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The gut microbiota-derived Pathogen-Associated Molecular Patterns, including LPS and peptidoglycan, are recognized by Pattern Recognition Receptors (PRRs), in particular Toll-like receptors and NOD-like receptors, which are expressed on osteoclasts and osteoblasts (236)

453 Pharmacological management Carbonic anhydrase inhibitor: acetazolamide While not specifically studied for HAPH, acetazolamide has beneficial effects on CMS, including reducing pulmonary vascular resistance and improving nocturnal oxygen saturation

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