Interestingly, a recent study by Qu et al., analyzing serum iron status biomarkers in nearly 24,000 European individuals, found that DAMD pathology was positively associated with transferrin levels and negatively associated with ferritin levels [196]
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The compounds were characterized by nuclear magnetic resonance (NMR) spectroscopy and high-resolution mass spectrometry (Supplementary Figs
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One very recent study of a TREM2 agonistic antibody in the cuprizone model reported enhanced myelin debris uptake and degradation, together with improved remyelination (Cignarella et al., Another approach could involve targeting lipid metabolism, as the uptake of too much cholesterol-rich myelin debris converts microglia into cells with a proinflammatory profile