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Within the hypothalamus the activation of GHS-1Ra in NPY and AgRP neurons is required for the orexigenic responses exerted by ghrelin release from A (X-like) cells in the stomach

In tandem, the arcuate nucleus of the hypothalamus, which contains both anorexigenic proopiomelanocortin-expressing neurons and orexigenic agouti-related protein/neuropeptide Y-co-expressing neurons, has a key role in the homeostatic control of food intake 4

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These differences help explain why GLP-1 drugs work best for people whose obesity is rooted in gut hormone dysfunction, while those with brain-based appetite signaling issues may respond better to older medications or drug combinations

Las dosis iniciales suelen ser ms bajas antes de aumentarlas hasta alcanzar la dosis objetivo