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Participants in the study discontinued treatment within 3 to 12 months, and researchers tracked their weight changes and subsequent treatments for one year after stopping the medication

Results fade gradually if treatment stops, as melanin production returns to baseline

Magnetic resonance spectroscopy (MRS) allows the insight into their pathophysiology through exploration of a range of biochemicals putatively relevant to aetiological processes, in particular mitochondrial dysfunction and energy metabolism

They are also known to be associated with reduced cardiovascular mortality in patients with type 2 diabetes, however cardiovascular benefit of these agents in non-diabetic patients have yet to be explored

1995 Jun;27(3):237-53