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Administration: subcutaneous injections

In neuronal cultures, direct treatment with TNF resulted in a time dependent decrease in mitochondrial respiration, followed by a reduction in cell viability correlated with increase cytosolic cytochrome c levels ( Neuroinflammation in epilepsy is commonly associated with blood brain barrier (BBB) disruption, allowing infiltration of the brain parenchyma by peripheral immune cells and serum albumin as reviewed in detail by Van Vliet et al

Antioxidants (Basel, Switzerland), 9(7)

However, animal physiology, controlled experimental conditions, and model-specific assumptions can diverge substantially from human biology

Lab evaluation is done on a case by case basis