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MOTS-C: The mitochondrial energy peptide MOTS-C is a mitochondrial-derived peptide

Essentially water-soluble this vitamin is commonly found in a variety of foods such as fish, shellfish, meat, eggs, and dairy products

Besides being the sole antioxidant enzyme able to repair lipid peroxides, GPX4 is a moonlighting protein that also regulate eicosanoid biosynthesis ( Hydroperoxides relevant to inflammation are those formed from arachidonic acid (AA) by stereoselective lipoxygenases

49 The interaction of ER-resident DnaJ/JDP (ERdj) 5 with EDEMs and OS9 promotes further glycan processing and breaks disulfide bonds of the misfolded glycoprotein, thereby enabling the misfolded glycoprotein to translocate from the ER into the cytoplasm

Moreover, evidence has been provided that p65 can interact with Keap1 promoting Nrf2 degradation [28]