The first generation of GLP-1 therapies exhibit reduced susceptibility to enzymatic degradation, while providing effective glucose control, improved -cell function, body weight loss and decreased systolic blood pressure in patients with T2D (Meier, 2012) The newly developed incretin mimetics, including albiglutide, dulaglutide and semaglutide, are designed to have extended pharmacokinetic profiles and efficacy suitable once-weekly administration
Patients should maintain realistic expectationsbowel habits vary individually, and 'normal' ranges from three times daily to three times weekly
In adults with overweight or obesity who completed a 20-week run-in on semaglutide 2.4 mg, mean weight fell by 10.6% before randomisation
Always have these stocked Fridge essentials: Pre-cooked chicken breast (shredded or sliced) Hard-boiled eggs (batch cook a dozen every Sunday) Greek yogurt (plain, high-protein variety) Cottage cheese Pre-made protein shakes (ready-to-drink bottles) Deli turkey or chicken slices String cheese Pantry essentials: Whey or plant-based protein powder Canned tuna or salmon Beef or turkey jerky Protein bars (20+ grams per bar) Canned chicken Freezer essentials: Frozen shrimp (thaws quickly for last-minute meals) Frozen fish fillets Frozen edamame Pre-portioned ground turkey When your kitchen is stocked with protein-first options, the default choice becomes the right choice
Risk of bias The risk of bias in the included randomized controlled trials (RCTs) was assessed using the revised Cochrane risk-of-bias tool (RoB2)
