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Stat Med 27 , 38053816 (2008)

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These pathways have simultaneously developed for organ-specific adaptation to meet the physiological demands specific to each organ, sensing glucose in pancreatic -cells for insulin secretion, and sensing various nutrients like amino acids, fatty acids, and glucose for GLP-1 secretion in intestinal L-cells 32

GHK-Cu operates through copper-mediated gene modulation, collagen remodeling, and antioxidant upregulation with a focus on extracellular matrix quality and skin/scar tissue architecture