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Like the WT receptor, the non-fused full-length C347K receptor remained inactive in the absence of exogenous peptides (Figure 5a, C347K FL lane labeled with red asterisk, see also Figure 4c and d)

GHK-Cu is found naturally in human plasma, saliva, and urine, and its concentration in plasma declines significantly with age, from approximately 200 ng/ml at age 20 to around 80 ng/ml by age 60