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However, in another study conducted in the UK, individuals with high-risk adenomas exhibited significantly lower serum IGFBP3 levels compared with those with low-risk adenomas and combined normal colonoscopy results ( P = 0.14/high risk with two group: 0.05) [80]

PMID: 20803613

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though the first use of the ligand for a brain-targeting prodrug of methotrexate was reported in 1991 [22]