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An upregulation of KYAT1 and AADAT may reflect a compensatory astrocytic response to diminished KYNA availability, whereby upregulation of KAT enzymes and glutamate uptake mechanisms attempts to restore NMDAR inhibition and stabilize glutamatergic tone

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Semaglutide is approved for multiple indications, including the treatment of type 2 diabetes (under the brand name Ozempic) and for weight management (under the brand name Wegovy)

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