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The therapeutic window for early failure is narrow (2448 h), whereas intervention for late failure may last several days to weeks

Brain Neuroplasticity in Healthy, Hyperactive and Psychotic Children: Insights from Neuroimaging

It is also an essential chemical for supporting heart and brain function and other body processes

There is some evidence for a temporal window of TABLE 3-6 Examples of Experimental Models of Repetitive TBI vulnerability, with repeated mild injuries in close temporal proximity producing greater damage than injuries separated by longer periods of time (in the case of rodents, a separation of seven days) (Longhi et al., 2005)

End of combination therapy was defined as the day that treatment with metformin, the exposure drug, or the control drug ceased or when another glucose-lowering drug was initiated