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Without extra support, you might face: Up to 66% of weight lost on GLP-1 medications can be regained within a year of stopping treatment

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Highlighting the crosstalk between the immune and endocrine system, the GLP-1 receptor is expressed on multiple immune cell populations, including intestinal intraepithelial lymphocytes (28, 29)

Some patients may show genetic patterns suggesting robust GLP-1 pathway activation, which could influence whether adding a DPP-4 inhibitor offers meaningful benefit or represents redundant pathway stimulation