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Of note, combination therapy faces significant barriers, including safety concerns in older or frail individuals, underutilisation in disadvantaged populations, while economic challenges may further hinder the accessibility of these therapies

225 Palmitoylethanolamide (PEA) PEA is an endocannabinoid-like bioactive lipid mediator used as a nutritional supplement primarily for its neurological, anti-inflammatory and analgesic effects

Mechanism: NAD is a critical coenzyme in mitochondrial energy metabolism, playing a central role in ATP production and cellular repair processes

Fish oil can sometimes contain contaminants like mercury or PCBs if its not purified properly

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