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The clinical consequences could range from local inflammation or rash through to serious health issues, such as systemic hypersensitivity, including anaphylaxis, or antibody formation

The peptides acidic residues (glutamate at position 2 and aspartate at position 3) have been proposed to facilitate interactions with chromatin-associated proteins and transcription regulatory complexes, consistent with observed epigenetic effects documented in in-vitro model systems

Response: We appreciate the comment for their general support of the inclusion of third-party intermediaries in the ASM data submission mechanisms

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