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For the primary composite outcome and secondary hierarchical outcomes, the threshold for two-sided statistical significance was set to 0.0322 (one-sided level 0.00161) using Lan-DeMets alpha spending function, which allows to adjust significance levels as data were reviewed for the interim analysis, reducing the chance of false positive results

The murine fibroblastic cell line L929 was used as a validation control for this procedure, and similar results were obtained (Supplementary Fig

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Diane Mueller and her work Listen Mapping BCAAs with Dr

Ela compartilha os principais resultados e suas observaes ao longo do trabalho