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Dose miscalculation is a common overdose cause

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GLP-1 RA therapy significantly improved both exercise capacity and HRQoL in individuals with obesity-related HFpEF regardless of diabetes status, but had no effect on these parameters in in HFrEF patients

As a non-peptide small molecule, it is taken once daily with no food, water, or timing restrictions, which removes the adherence friction that limits oral semaglutide

These effects were more common in the semaglutide group than in the placebo group