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Ethylenediamine was then coupled using a DCC/NHS reaction after deprotection

The brief duration of action means that endogenous GLP-1 functions as a meal-related signal rather than providing sustained metabolic control

Primary discontinuation was defined as the first date a patient went 60 days or more without any GLP-1based treatment on hand, using fill dates and number of days of medication supplied to account for excess (carryover) medication from previous fills

45 Clinicians should not limit the use of GLP-1 receptor agonists and deny potential medical benefits to patients because of a history of pancreatitis or a likelihood of developing pancreatitis