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P = 0.004), in comparison with 2 mg, for the treatment policy estimand and the hypothetical estimand, respectively, and of 2.5 kg (not statistically significant) and 4.2 kg in comparison with 8 mg (Fig

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Monitoring protocol A structured approach to heart rate monitoring provides early warning if effects are trending toward concerning territory: Baseline measurement: Before starting retatrutide, measure resting heart rate for 5 consecutive mornings immediately upon waking (before getting out of bed, before coffee, before checking your phone)