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The second step in glutathione (GSH) synthesis is catalyzed by the enzyme Glutathione Synthase (GS, EC 6.3.2.3, formerly known as GSH synthetase)

Nevertheless, the improvement in lipid tolerance was similar in mice receiving the 2 different doses of sitagliptin (Figure 1C), highlighting the importance of DPP-4 + cells within the gut for control of lipid tolerance

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