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Several factors may increase the likelihood of experiencing heartburn on semaglutide

It works by mimicking the GLP-1 hormone, which helps regulate appetite, reduce hunger, and lower calorie intake, thereby supporting sustainable weight loss when combined with a reduced-calorie diet and increased physical activity

These included nausea, vomiting, diarrhea, and constipation

For example, the STEP 3 trial combined the medication with intensive behavioral therapy, leading to impressive results

While both formulations contain identical active medication, their pharmacokinetic profiles differ significantly due to their routes of administration